New chlamydosporol derivatives from the endophytic fungus Fusarium sp. #001

Abstract

Two new chlamydosporol derivatives, fusarilactone A (1) and fusarilactone B (2), together with nine known compounds (3–11), have been isolated from the crude extract of endophytic fungus Fusarium sp. #001. The structures of new compounds 1 and 2 were elucidated on the basis of extensive spectroscopic methods. Compound 1 showed mild cytotoxicities against three tumor cell lines (SMMC-7721, A-549, and MCF-7).

Keywords::

• endophytic fungi
• chlamydosporol derivatives
• Fusarium sp
• Eupatorium adenophorum
• cytotoxicity

Acknowledgments

This project was financially supported by National Natural Science Foundation of China (U1132607) and Youth Innovation Promotion Association of CAS (2011312D11019).