Abstract
A series of 4β N-indole-substituted podophyllotoxin derivatives were synthesized. Nine target compounds were evaluated against human cancer cell lines (HeLa, K562, and K562/A02) using MTT assay including three imine derivatives 8, 9, and 10in vitro. The result showed that the three compounds had higher antitumor activity than their reduced forms. Among them, compounds 8, 9, 11, and 16 were superior to the positive control VP-16.
Keywords::
Acknowledgments
This work was financially supported by the National Natural Science Foundation of China (No. 30873363), the Great Program of Science Foundation of Tianjin (No. 09ZCKFNC01200), and the Program of Science Foundation of Tianjin (No. 08JCYBJC070000).