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Abstract
Talaflavuterpenoid A (1), a new nardosinane-type sesquiterpene, was isolated from the wetland soil-derived fungus Talaromyces flavus BYD07-13, and its structure was elucidated on the basis of HR-MS, NMR, and X-ray diffraction analysis. The absolute configuration of 1 was established by comparing the experimental electronic circular dichroism (ECD) spectrum with the calculated ECD spectra. Its cytotoxic effects on five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480), and antimicrobial activity against Escherichia coli, Staphylococcus aureus, Candida albicans, and Aspergillus niger were evaluated. This is the first report of the presence of nardosinane-type sesquiterpene in Talaromyces sp.
Acknowledgments
This work was financially supported by grants from Technology of China (no. 2012ZX09301002003), by the Natural Science Foundation of China (no. 81373306), by Guangdong Natural Science Funds for Distinguished Young Scholar (no. S2013050014287), by the program for New Century Excellent Talents in University (no. NCET-10-0120), by Fok Ying Tung Education Foundation (no. 121039) from the Ministry of Education of China, and by the high-performance computing platform of Jinan University.
Notes
1. These authors contributed equally to this work.
2. Current address: Research Center of Natural Resourses of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, P.R. China.
