Studies on chemical constituents of Ophiopogon japonicus

Abstract

Two new and six known steroidal glucosides were isolated from the tuber of Ophiopogon japonicus. The new steroidal glucosides were established as (20R,25R)-26-O-β-d-glucopyranosyl-3β,26-dihydroxycholest-5-en-16,22-dioxo-3-O-α-l-rhamnopyranosyl-(1 → 2)-β-d-glucopyranoside (1) and 26-O-β-d-glucopyranosyl-(25R)-furost-5-en-3β,14α,17α,22α,26-pentaol-3-O-α-l-rhamnopyranosyl-(1 → 2)-β-d-glucopyranoside (3) on the basis of spectroscopic data as well as chemical evidence.

Keywords::

• Ophiopogon japonicus
• Liliaceae
• steroidal glucoside

Acknowledgments

The authors were financially supported by the International Science & Technology Cooperation Program of Commission and the Innovative Team of Beijing TCM University (no. 2011-CXTD-19) and the programs of Jilin Province Administration of Traditional Chinese Medicine (Nos. 2010-pt036; 2011-zd15; YJS-0212).