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Articles

A new symmetrical tetramer oligostilbenoid containing tetrahydrofuran ring from the stem bark of Dryobalanops lanceolata

, , , , , & show all
Pages 1099-1107 | Received 14 Jan 2014, Accepted 19 Jun 2014, Published online: 18 Jul 2014
 

Abstract

A new tetramer oligostilbenoid possessing tetrahydrofuran ring, malaysianol C (1), was isolated from the acetone extract of the stem bark of Dryobalanops lanceolata, together with four known oligostilbenoids nepalensinol E (2), ϵ-viniferin (3), laevifonol (4), and ampelopsin F (5). The structures of isolated compounds were elucidated on the basis of spectral evidence. The antibacterial activity of the isolated compounds was evaluated using resazurin microtitre-plate assay, whereas the cytotoxic activity was tested using MTT assay. The plausible biogenetic routes of the isolated compounds are also discussed.

Acknowledgments

The authors would like to thank The Ministry of Higher Education, Malaysia for the financial support under the Fundamental Research Grant Scheme [600-RMI/ST/FRGS/5/3/FST (12/2010)], and Prof. Dr Teh Lay Kek, Pharmacogenomics Institute (iPROMISE), UiTM Puncak Alam, Malaysia for the mass spectrometer measurement of samples.

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