α-Glucosidase and lipoxygenase inhibitory derivatives of cryptosporioptide from the endophytic fungus Cryptosporiopsis sp.

Abstract

Two new cryptosporioptide-derived polyketides cryptosporioptides A (2) and B (3) were isolated from the extract of endophytic fungus Cryptosporiopsis sp. associated with the shrub, Viburnum tinus. The structures of the isolates were determined through spectral analysis including 1D NMR (¹H, ¹³C) and 2D NMR (HSQC, HMBC, COSY) techniques, HR-FAB-MS and by comparison with the reported data of cryptosporioptide (1). The relative stereochemistry was assigned with the help of NOESY analysis, the molecular model, and comparison of the optical rotation values with the reference compound 1.

Keywords::

• Cryptosporiopsis fungus
• isolation
• structure elucidation
• cryptosporioptide derivatives
• enzyme inhibition

Acknowledgments

The corresponding author is thankful to AvH Foundation, Germany, for providing financial support in the form of equipment subsidy. M.I. Tousif is obliged of HEC for the award of research scholarship.