Three new sesquiterpenoids from cultures of the basidiomycete Conocybe siliginea

Abstract

Three new sesquiterpenoids (1–3), along with four known compounds (4–7), were isolated from cultures of the fungus Conocybe siliginea. The structures of new compounds were elucidated using spectroscopic methods. The known compounds were identified by comparing their spectroscopic data with those reported in the literature. All new compounds were evaluated for cytotoxicity against five human cancer cell lines, but none of them possesses significant activity (IC₅₀>40μM).

Keywords::

• Conocybe siliginea
• sesquiterpenoids
• cytotoxicity

Acknowledgments

This project was financially supported by the National Natural Sciences Foundation of China (Nos U1132607, 81102346) and the Youth Innovation Promotion Association, Chinese Academy of Sciences (No. 2011312D11019).