Two new terpenoids from the stems of Manihot esculenta

Abstract

A new eremophilane sesquiterpene, sporogen AO-2 (1), and a new beyerane diterpene, thecacorin C (2), together with two known compounds, longifoamide-B (3) and methylcholestane-3β,5α,6β-triol (4), were isolated from the stems of Manihot esculenta. The structures of the two new compounds were determined by spectroscopic techniques (UV, IR, MS, 1D, and 2D NMR). Antimicrobial assay showed that compound 3 possessed modest inhibitory effects on Saphylococcus aureus and methicillin-resistant S.aureus, diameters of inhibition zones of which were 7.5 and 8.0 mm, respectively. Compound 4 possessed modest inhibitory effect on S. aureus, the diameter of inhibition zone of which was 6.8 mm.

Keywords::

• Euphorbiaceae
• Manihot esculenta
• sporogen AO-2
• thecacorin C
• antimicrobial
• Saphylococcus aureus

Acknowledgments

This research was financially supported by a Major Project of Chinese National Programs for Fundamental Research and Development Grants (2010CB126606), Special Fund for Agro-scientific Research in the Public Interest (201303117), and National Support Science and Technology Subject (2013BAI11B04).

Disclosure statement

No potential conflict of interest was reported by the authors.

Notes

^1. These authors contributed equally to this work.