Adlumiceine methyl ester, a new alkaloid from Fumaria vaillantii

Abstract

A new alkaloid, adlumiceine methyl ester (1), together with two known alkaloids, parfumine (2) and N-methylhydrastine methyl ester (3), was isolated from aerial parts of Fumaria vaillantii. The structures of compounds were determined by 1D/2D NMR and MS data. All three compounds were tested for cytotoxic activity against PC3 and MCF7 cell lines using Alamar blue assay. The tested compounds showed no significant cytotoxic activity (IC₅₀>50 μM) against PC3 and MCF7 cell lines.

Keywords::

• Fumaria
• Papaveraceae
• alkaloids
• parfumine
• N-methylhydrastine methyl ester

Acknowledgements

This research was financially supported by grants from the Mashhad University of Medical Sciences Research Council (Grant No. 910148). This study was also a part of the dissertation of Mrs Hamideh Javidi-Shirazi for the degree of Doctor of Pharmacy submitted to the School of Pharmacy, Mashhad University of Medical Sciences.

Conflict of interest

The authors declare no conflict of interest.