Abstract
Three new dihydroxanthones, muroxanthenones A–C (1–3), together with three known dihydroxanthones (4–6) were isolated from the fermentation products of an endophytic fungus Gliomastix murorum. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compound 3 showed high cytotoxicities against NB4 and PC3 cell with IC50 values of 2.2 and 2.8 μM. The other compounds also showed moderate cytotoxicities for some tested cell lines with IC50 values between 4.1 and 9.5 μM.
Acknowledgements
This research was supported by the National Natural Science Foundation of China (No. 21462051), the Applied Basic Research Combined Project of Yunnan Technology Bureau and Kunming Medical University (No. 2011FB124), and the Scientific Research Fund Key Project of Education Department of Yunnan Province (No. 2013Z038).