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Abstract
Four new stilbene derivatives, hypargystilbenes B-E (1–4), together with seven known compounds (5–11), were isolated from the stems of Artocarpus nanchuanensis S.S. Chang. Their structures were elucidated on the basis of spectral data. Hypargystilbene B, hypargystilbene D, and hypargystilbene E exhibited protein tyrosine phosphatase 1B inhibitory effects with corresponding IC50 values of 3.23, 37.31, and 2.53 nM.
Acknowledgment
We thank Prof. Jia Li at Shanghai Institute of Materia Medica, Chinese Academy of Sciences for the evaluation of PTP1B inhibition activity.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was financially supported by National Natural Science Foundation of China [grant number 20932007], [grant number 21172214], [grant number 81360475] and National New Drug Innovation Major Project of China [grant number 2011ZX09307-002-02].