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Abstract
A new cytotoxic benzophenanthridine isoquinoline alkaloid, named cordatine (1), together with one known alkaloid 8-methoxydihydrochelerythrine (2), was isolated from the fruits of Macleaya cordata. The structure of the new compound was elucidated by spectroscopic methods including 1D and 2D NMR, HR-ESI-MS. Both compounds indicated significant cytotoxicity against MCF-7 and SF-268 cell lines.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
We gratefully acknowledge the financial support from the Chinese National S&T Special Project on Major New Drug Innovation (2011ZX09307-002-01).