Three new iridoids from leaves of Cornus officinalis

Abstract

Three new iridoids, cornifins A–C (1–3), together with a known iridoid, were obtained from EtOAc layer of leaves of Cornus officinalis. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses. Compound 2 showed weak inhibitory activity against lung cancer cell line A-549 with IC₅₀ value of 29.1  μM.

Keywords::

• Cornaceae
• Cornus officinalis
• iridoids
• cornifins A–C
• structure and cytotoxicity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by Industry, Education, and Academy Program of Henan Province [grant number 142107000029].