Chemical constituents from Euphorbia wallichii and their biological activities

Abstract

One rare diterpenoid which was an unusual phorbol derivative possessing a 5-ene-7-oxo functional group, wallichiioid A (1), and 17 known compounds (2–18) were isolated from the aerial parts of Euphorbia wallichii. The structures and relative configuration of these compounds were elucidated on the basis of extensive spectroscopic interpretation. All the known compounds were isolated from E. wallichii for the first time. Diterpenoids 1–5 were tested for their cytotoxicity against five cancer cell lines (A-549, MCF-7, Hep G2, HeLa, and P388) and showed IC₅₀ values in the range of 8.19–29.72 μg/mL. The antiangiogenic activities of diterpenoids 1–5 were also evaluated using a zebrafish model.

Keywords::

• Euphorbia wallichii
• diterpenoid
• wallichiioid A
• cytotoxicity
• antiangiogenic activities

Acknowledgements

This project was supported financially by the National Natural Science Foundation of China (31300293 and 81202584), the General Project of Applied Foundation Research, Yunnan Province (2013FB067), the Basic Research Project of Ministry of Science and Technology of China (2012FY110300), and the Major State Basic Research Development Program (2010CB951704).

Disclosure statement

No potential conflict of interest was reported by the authors.

Notes

^1. These authors contributed equally to this article.