Four new neolignan glucosides from the fruits of Arctium lappa

Abstract

Four new neolignan glucosides named (7S, 8R)-4,7,9,9′-tetrahydroxy-3,3′-dimethoxy-8-O-4′-neolignan-9′-O-β-d-apiofuranosyl-(1 → 6)-O-β-d-glucopyranoside (1), (8R)-4,9,9′-trihydroxy-3,3′-dimethoxy-7-oxo-8-O-4′-neolignan-4-O-β-d-glucopyranoside (2), (7R, 8S)-dihydrodehydrodiconiferyl alcohol-7′-oxo-4-O-β-d-glucopyranoside (3), and (7′S, 8′R, 8S)-4,4′,9′-trihydroxy-3,3′-dimethoxy-7′,9-epoxylignan-7-oxo-4-O-β-d-glucopyranoside (4) were isolated from the fruits of Arctium lappa L. Their structures and absolute configurations were elucidated on the basis of comprehensive spectroscopic analyses (UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with known analogues in the literature.

Keywords::

• Arctii Fructus
• Arctium lappa
• neolignan glucosides
• absolute configuration

Acknowledgments

This research was financially supported by the Nation Science and Technology Project of China (No. 2012ZX09301002-002) and Fundamental Research Funds for the Central Institutes (No. 2015CX02).

Disclosure statement

No potential conflict of interest was reported by the authors.

Notes

Dedicated to Professor Xin-Sheng Yao for his eighty years birthday and his great contribution to Natural Product Research