Iridoid constituents from the male flower of Eucommia ulmoides and their promotion proliferation on ESF-1

Abstract

Four new iridoids (1, 2, 12, and 13), together with nine known iridoids (3–11), were isolated from the male flowers of Eucommia ulmoides Oliver and were characterized as 3β-methoxyartselawnin C (1), 6β-hydroxyl-1β,3β-dimethoxyartsclaenin III (2), 3,4-dihydro-3β-ethoxyasperuloside (12) and 3,4-dihydro-3β-ethoxydesacetylasperuloside (13) by extensive analyses of their 1D and 2D NMR spectroscopy and mass spectra. All of the isolated compounds were assayed for the promoting proliferation of skin fibroblasts cell (ESF-1) and compounds 4 and 7 (5 μM) significantly stimulated the proliferation of ESF-1 cells.

Keywords::

• Eucommia ulmoides
• iridoids
• promotion proliferation
• ESF-1

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financed by the Major State Basic Research Development Program of China (No. 2013CB531803) and Program for Liaoning Innovate Research Team in University (LT2013020).