Two new illudin type sesquiterpenoids from cultures of Phellinus tuberculosus and Laetiporus sulphureus

Abstract

Chemical investigation on the cultures of Phellinus tuberculosus and Laetiporus sulphureus lead to the isolation of two new illudin-type sesquiterpenoids (phellinuin J and sulphureuine A). Their structures were elucidated by 1D, 2D NMR and MS spectroscopic data. These compounds were purposely evaluated for their cytotoxicity against HL-60, SMMC-7721, A549, MCF-7, and SW480 cell lines.

Keywords::

• Hymenochaetaceae
• Phellinus tuberculosus
• Laetiporus sulphureus
• sesquiterpenoids
• phellinuin J
• sulphureuine A

Additional information

Funding

This project was financially supported by the National Natural Sciences Foundation of China [grant number U1132607], [grant number 81102346]; Natural Sciences Foundation of Yunnan Province [grant number 2011FB099]; West Light Foundation of The Chinese Academy of Sciences [grant number 2013312D11016].