A new cyclolignan glycoside from the tubers of Pinellia ternata

Abstract

A new 2,7′-type cyclolignan glycoside, cyclolignanyingoside A (1), together with six known compounds (2–7) were isolated from the tubers of Pinellia ternata (Thunb.) Breit. The structure of 1 was elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses, HR-ESI-MS, and CD spectrometry. The cytotoxic, antioxidant and tyrosinase-inhibiting activities of all the isolates were determined. However, all the isolates exhibited no activity on the selected cell lines (Hep-3B, Bcap-37, and MCF-7). In addition, compounds 1–3 and 7 exhibited strong 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) free radical scavenging activity, and compounds 2 and 4 showed a moderate mushroom tyrsinase inhibitory activity.

Keywords::

• Araceae
• Pinellia ternata
• cyclolignan glycoside
• cytotoxic activity
• antioxidant activity
• tyrosinase-inhibiting activity

Acknowledgements

Authors thank Mrs Wen Li. and Mr Yi Sha of Shenyang Pharmaceutical University for recording of NMR spectra.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Financial supports from the National Natural Sciences Foundation of China (Nos 81130071 and 81373925) and Program for Liaoning Excellent Talents in University (LR2012034).