New C₁₃ lipids from the marine-derived fungus Trichoderma harzianum

Abstract

Chemical examination of the fermentation broth of a sponge-associated fungus Trichoderma harzinum HMS-15-3 led to the isolation of four pairs of new C₁₃ lipid enantiomers namely harzianumols A–H (1a–4b). Their structures were elucidated on the basis of extensive spectroscopic (IR, MS, 1D, and 2D NMR) data analysis, including the modified Mosher's method for the assignment of their absolute configurations. The new compounds were evaluated for antihyperlipidemic effects in HepG2 cells.

Keywords::

• Trichoderma harzinum
• harzianumols A–H
• structural elucidation

Disclosure statement

No potential conflict of interest was reported by the authors.

Notes

This paper is dedicated to the 80th birthday of Prof. Xin-Sheng Yao for his contribution to natural product chemistry.

^1. These authors contributed equally to this paper.

Additional information

Funding

This work was financially supported by grants from the National Basic Research Program 973 [grant number 2015CB755900]; NSFC-Shangdong Joint Fund for Marine Science [grant number U1406402]; COMRA [grant number DY125-15-T-01]; and Sino-German Project [GZ816].