Bioactive prenylated xanthones from the stems of Cratoxylum cochinchinense

Abstract

Cochinchinones M–U (1–9), together with 12 known compounds (10–21), were isolated from the stems of Cratoxylum cochinchinense (Lour.) Blume. Their structures were determined on the basis of extensive spectroscopic data analyses. In addition, their retinoid X receptor-α transcriptional activities were evaluated using an in vitro assay.

Keywords::

• Guttiferae
• Cratoxylum cochinchinense
• xanthone
• RXRα transcriptional activity

Acknowledgments

We thank Professor Rong-tao Li (Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences) for collecting the plant material. We are grateful to Dr Tao Shi and Dr Jiefeng Tian for measuring the HR-ESI-MS and NMR data.

Disclosure statement

No potential conflict of interest was reported by the authors.

Notes

Dedicated to Professor Xin-Sheng Yao on the occasion of his 80th birthday.

^1. These authors contributed equally to this work.

Additional information

Funding

This work was supported by grants from the National Natural Science Foundation of China [grant number NSFC-30873146], [grant number NSFC-91129302]; China Postdoctoral Science Foundation Funded Project [grant number 2011M500138]; State Key Laboratory of Drug Research [grant number SIMM1203KF-09]; and Programme of Introducing Talents of Discipline to Universities [grant number B13038].