Cyclohexenones and isocoumarins from an endophytic fungus of Sarcosomataceae sp.

Abstract

Three new cyclohexenones (1–3, named sarcosones A–C) and two new isocoumarins (4 and 5), together with five known isocoumarins (6–10), were isolated from the solid cultures of an endophytic fungus Sarcosomataceae sp. NO.49-14-2-1. Their chemical structures were elucidated by analyses of HR-ESI-TOF-MS, ¹H, ¹³C NMR, ¹H–¹H COSY, HSQC, and HMBC spectra. Their absolute configurations were determined via modified Mosher's method and circular dichroism spectra method.

Keywords::

• Endophytic fungus
• Sarcosomataceae sp
• cyclohexenone
• isocoumarin

Acknowledgements

The authors are grateful to Mr Tao Shi and Jian-Liang Geng for the HR-ESI-MS measurements. Dr Guo-Dong Chen's enthusiastic help in gene sequence analysis and uploading is also appreciated.

Disclosure statement

No potential conflict of interest was reported by the authors.

Notes

Dedicated to Professor Xin-Sheng Yao on the occasion of his 80th birthday.

Additional information

Funding

This work was financially supported by grants from the Ministry of Science and Technology of China [grant number 2012ZX09301002003]; by Guangdong Natural Science Funds for Distinguished Young Scholar [grant number S2013050014287]; by the program for New Century Excellent Talents in University [grant number NCET-10-0120]; and Fok Ying Tung Education Foundation [grant number 121039] from the Ministry of Education of China.