Two new phenylpropanoids and one new sesquiterpenoid from the bioactive fraction of Sambucus williamsii

Abstract

Two new phenylpropanoids, samwirin (1) and samwiphenol (2), and a new sesquiterpenoid, 2β,4β,10α-trihydroxy-1αH,5βH-guaia-6-ene (3), together with six known compounds were isolated from the bioactive fraction of Sambucus williamsii Hance. Their structures including the absolute configurations were characterized on the basis of extensive 1D, 2D-NMR, MS, and CD spectral data. In vitro proliferation effects of all compounds on osteoblast-like UMR 106 cells were examined. Compounds 1, 4–9 significantly promoted cell proliferation. Compounds 5, 6, and 8 increased osteoblastic cell numbers separately by 24.3%, 25.2%, and 29.1% at 10^–10 M, 10^–10 M, and 10^–8 M, respectively.

Keywords::

• Caprifoliaceae
• Sambucus williamsii
• phenylpropanoid
• sesquiterpenoid
• proliferation effects
• UMR 106 cells

Acknowledgements

We thank the State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), Shenzhen for its support.

Disclosure statement

The authors have no conflict of interests to declare.

Notes

Dedicated to Professor Xin-Sheng Yao on the occasion of his 80^th birthday.

Additional information

Funding

This work was financially supported by the Central Research Fund of the Hong Kong Polytechnic University (GU324, GU256, GYM-47), the National Basic Research Program of China (973 program, 2012CB723506), the Shenzhen Key Laboratory Advancement Program (CXB201104220020A), the Shenzhen Basic Research Program (JCYJ20140819153305697), the National Natural Science Foundation of China (81202894, 81220108028) as well as the National Major Scientific and Program of Introducing Talents of Discipline to Universities (B13038).