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Abstract
Four spiroalkaloids, including a new compound shensongine A (1), were isolated from the anti-arrhythmic TCM formula Shensong Yangxin capsule. Their structures were determined on the basis of spectroscopic analysis. Compounds 1 and 3 displayed cardiovascular activities by shortened APD in rat myocardial cells. These compounds were possibly generated from precursors in different composed herbal medicines during the processing of the TCM formula.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Notes
This paper is dedicated to Professor Xin-Sheng Yao on the occasion of his 80th birthday.
Additional information
Funding
This work was financially supported by grants from the Ministry of Science and Technology of China with the Key Drug Discovery Project of 12th Five-year plan [grant number 2011ZX09201-201-28].
