A new bisabolane-type sesquiterpenoid from the fermentation broth of fungus Antrodiella gypsea

Abstract

Studies of the fermentation broth of fungus Antrodiella gypsea led to the isolation of a new bisabolane-type sesquiterpenoid that was named gypseatriol (1), together with the known compound 2,10-dodecadiene-1,6,7-triol (2). The structure of this new metabolite was assigned by analysis of 2D NMR and HR-EI-MS. Absolute configuration was assigned by single crystal X-ray diffraction analysis. Compound 1 was evaluated for its antifungal activity on Candida albicans.

Keywords::

• Basidiomycete
• Antrodiella gypsea
• bisabolane
• sesquiterpenoid

Additional information

Funding

This work was financially supported by the Natural Science Foundation of Yunnan Province [grant number 2011FB099]; West Light Program of CAS [grant number 2013312D11016].