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Abstract
A new steroidal ketone (1), with an ergosta-22,25-diene side chain, was obtained from the South China Sea marine sponge Xestospongia testudinaria. The structure of 1 was determined on the basis of detailed spectroscopic analysis and by comparison with literature. Compound 1 exhibited significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a key target for the treatment of type II diabetes and obesity, with an IC50 value of 4.27 ± 0.55 μM, which is comparable with the positive control oleanolic acid (IC50 = 2.63 ± 0.22 μM).
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No potential conflict of interest was reported by the author(s).
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Funding
This research work was financially supported by the Natural Science Foundation of China [grant number 81273430], [grant number 41306130], [grant number 81302692] and [grant number 41476063]; the National Marine ‘863’ Project [grant number 2012AA092105], [grant number 2013AA092902]; the China Postdoctoral Science Foundation [grant number 2012M520956], [grant number 2014T70443], SCTSM Project [grant number 14431901100]; and was partially funded by the EU 7th Framework Programme-IRSES Project [grant number 246987].