Two new lignans from twigs of Aglaia odorata

Abstract

HPLC-guided separation of twigs of Aglaia odorata led to the isolation of eight lignans, including two new ones, 3′-methoxy-N-demethylrocaglamide (1) and 4′-O-demethyl-deacetylaglaxiflorin A (2). Compound 1 showed excellent cytotoxicity against three human cancer cell lines, HeLa, SGC-7901 gastric cancer, and A-549 lung cancer with the values of 0.32, 0.12, and 0.25 μM, respectively.

Abstract

Keywords::

• Meliaceae
• Aglaia odorata
• 3′-methoxy-N-demethylrocaglamide
• 4′-O-demethyl-deacetylaglaxiflorin A
• cytotoxicity

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China [grant number 21172225], [grant number 31370377); the Young Academic and Technical Leader Raising Foundation of Yunnan Province [grant number 2010CI049]; and XiBuZhiGuang Project of the Chinese Academy of Sciences.