Three new compounds from Cinnamomum cassia

Abstract

Three new compounds, including two new diterpenoids, named epianhydrocinnzeylanol (1) and cinnacasiol H (2), and one hydroxylasiodiplodin, (3R,4S,6R)-4,6-dihydroxy-de-O-methyllasiodiplodin (3), together with five known diterpenoids (4–8) and two known phenolic glycosides (9–10) were isolated from the barks of Cinnamomum cassia. Their structures were elucidated by extensive spectroscopic analysis and comparison of the chemical shift values with those of related known compounds. The anti-inflammatory activities of the isolates were evaluated on nitric oxide production in lipopolysaccharide-induced BV-2 microglial cells and the compounds showed weak inhibition activities.

Keywords::

• Cinnamomum cassia
• chemical constituents
• diterpenoids
• hydroxylasiodiplodin
• anti-inflammatory activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was financially supported by National Natural Sciences Foundation of China [grant number 81222051], and National Key Technology R&D Program “New Drug Innovation” of China [grant number 2012ZX09301002-002-002], [grant number 2012ZX09304-005].