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Abstract
Four new guanacastane-type diterpenoids, namely dahlianes A (1), B (2), C (3), and D (4), were isolated from cultures of Verticillium dahliae. Their structures were elucidated on the basis of extensive spectroscopic data analysis. Their absolute configurations were determined by a combination of Mo2(OAc)4-induced electronic circular dichroism experiment and Mosher ester method. In cytotoxicity evaluation against human tumor cell lines, compounds 2 and 3 exhibited significant cytotoxicities against MCF-7 cell lines with IC50 values of 3.35 and 4.72 μM, respectively.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was funded by the Fundamental Research Funds for the Central Universities [JKQZ2013016], the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), the Youth Fund Project of Basic Research Program of Jiangsu Province (Natural Science Foundation, [BK20130651]), the Program for Changjiang Scholars and Innovative Research Team in University [IRT1193], and the National Natural Science Foundation of China [81073009].