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Abstract
Eleven novel ursolic acid (UA) derivatives were designed and synthesized with modification at positions of C-2, C-3, and C-28 of UA. Their structures were confirmed by MS, 1H NMR, and elemental analysis. Their in vitro cytotoxicities against various cancer cell lines (HeLa, HepG2, and BGC-823) were evaluated by MTT assay. The results indicated that all compounds could inhibit cell proliferation of HeLa, HepG2, and BGC-823 cells. Among them, compounds I3 and I4 showed more potent cytotoxicity on these three tumor cells than gefitinib (positive control), worthy to be studied further.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was supported by the Natural Science Foundation of China [No. 21372156], Program for Liaoning Excellent Talents in University [No. LR2013017], Program of Science and Technology in Shenyang of China [No. F13-316-1-47].