Two new 13,14:14,15-disecopregnane-type compounds from the roots of Cynanchum paniculatum

Dan ZhaoSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China

Hai-Feng WangSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China

Gang ChenSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China

Yi-Peng LiYangtze River Pharmaceutical Group Pharmaceutical Co., Shanghai Haini, Shanghai201318, China

Hui-Ming HuaSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China

Yue-Hu PeiSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, ChinaCorrespondence[email protected]

Abstract

Two new 13,14:14,15-disecopregnane-type compounds glaucogenin F (1), glaucogenin F 3-O-β-D-oleandropyranoside (2), together with three known compounds cynapanoside A (3), cynatratoside A (4), and neocynapanogenin F 3-O-β-D-oleandropyranoside (5) were isolated from the 95% ethanol extract of the roots of Cynanchum paniculatum. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses, including 1D and 2D NMR, HRESIMS and NOESY.

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Acknowledgment

This paper was financially supported by Program for Innovative Research Team of the Ministry of Education and Program for Liaoning Innovative Research Team in University.

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No potential conflict of interest was reported by the authors.

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Two new 13,14:14,15-disecopregnane-type compounds from the roots of Cynanchum paniculatum

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Two new 13,14:14,15-disecopregnane-type compounds from the roots of Cynanchum paniculatum

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