Two new γ-pyrone glucosides from Paeonia albiflora

Abstract

Two new γ-pyrone glucosides, along with three known compounds, were isolated from the roots of Paeonia albiflora, and their structures were elucidated by spectral experiments, chemical analysis, and comparison with literature data. The structures of the new compounds were established as 2-(hydroxymethyl)-4-oxo-4H-pyran-3-yl-6-O-α-L-rhamnopyranosyl-β-D-glucopyranoside (1), and 2-(hydroxymethyl)-4-oxo-4H-pyran-3-yl-6-O-galloyl-β-D-glucopyranoside (2). The inhibitory activity on the release of TNF-α of compounds 1–5 was evaluated in vitro. This is the first report of the presence of γ-pyrone glucoside in P. albiflora.

Keywords:

• Paeonia albiflora
• γ-pyrone glucosides
• chemical constituents

Funding

This work was financially supported by Guangdong Natural Science Fund [grant number S2013030011515]; Guangdong Financial Industry Technology Research Development Fund [grant number 2011(285)05]; Guangdong Science and Technology Department-Guangdong Province Academy of Chinese Medicine Science Joint Special Fund [grant number 2011B032200009]; Guangdong Provincial Hospital of Chinese Medicine Special Fund [grant number YK2013B1N11].