Terpenoids from the roots of Alangium chinense

Abstract

Two new norditerpenoids (1 and 2), four new sesquiterpenoids (3–6), and 22 known compounds (7–28) were isolated from an ethanolic extract of roots of Alangium chinense. The absolute configurations of 1–6 were assigned by experimental and calculated ECD spectra. The skeleton of the compounds (1 and 2) has been reported only one time so far. Compounds 1, 13, and 23 exhibited antiviral activity against coxsackie virus B3 with IC₅₀ values of 38–67 μM. Compounds 8 and 9 displayed neuritis inhibitory activity against microglial inflammation factor, with IC₅₀ values of 6.4 and 10.1 μM, respectively. None of the compounds were cytotoxic in the MTT assay.

Keywords:

• Alangiaceae
• terpenoids
• Alangium chinense
• antiviral
• coxsackie virus B3

Acknowledgments

The authors are grateful to the Department of Instrumental Analysis at our institute for UV, IR, NMR, and MS spectra measurements.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by grants from the National Natural Science Foundation of China [grant number 21132009], [grant number 21302226]; the National Science and Technology Project of China [grant number 2012ZX09301002-002].