Abstract
Three new C20-diterpenoid alkaloids vilmorrianines E (1), F (2), and G (3) were isolated from the whole plants of Aconitum vilmorrianum, along with one artifact N-chloromethyl vilmorrianine E hydrochloride (4), as well as two known alkaloids hemsleyaconitines F (5) and G (6). The structures of 1–4 were established by HR-ESI-MS, 1D-, 2D-NMR (HMQC, HMBC, and NOESY), and single-crystal X-ray diffraction analysis. In addition, the structures of naturally occurring 2-O-acetylorochrine (7) and orochrine (8) were revised to be the known alkaloids heterophylloidine (9) and deacetyl heterophylloidine (10), respectively, on the basis of consideration of transannular effect and chemical correlations.
Acknowledgments
The authors would also like to thank Professor Xian-Li Zhou (School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China) and Dr Li-Sheng Ding (Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China) for measuring HR-ESI-MS and providing compound heterophylloidine, respectively.
Disclosure statement
No potential conflict of interest was reported by the authors.