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Articles

New C20-diterpenoid alkaloids from Aconitum vilmorrianum and structural revision of 2-O-acetylorochrine and orochrineFootnote

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Pages 315-327 | Received 04 Jun 2015, Accepted 15 Aug 2015, Published online: 19 Oct 2015
 

Abstract

Three new C20-diterpenoid alkaloids vilmorrianines E (1), F (2), and G (3) were isolated from the whole plants of Aconitum vilmorrianum, along with one artifact N-chloromethyl vilmorrianine E hydrochloride (4), as well as two known alkaloids hemsleyaconitines F (5) and G (6). The structures of 14 were established by HR-ESI-MS, 1D-, 2D-NMR (HMQC, HMBC, and NOESY), and single-crystal X-ray diffraction analysis. In addition, the structures of naturally occurring 2-O-acetylorochrine (7) and orochrine (8) were revised to be the known alkaloids heterophylloidine (9) and deacetyl heterophylloidine (10), respectively, on the basis of consideration of transannular effect and chemical correlations.

Acknowledgments

The authors would also like to thank Professor Xian-Li Zhou (School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China) and Dr Li-Sheng Ding (Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China) for measuring HR-ESI-MS and providing compound heterophylloidine, respectively.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Nature Science Foundation of China [grant number 81273387].

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