Three new monoterpenoid indole alkaloids from Vinca major

Zhi-Jun ZhangFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming650500, China;State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming650204, China

Ru-Nan DuState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming650204, China

Juan HeState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming650204, China

Xing-De WuState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming650204, China

Yan LiState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming650204, China

Rong-Tao LiFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming650500, ChinaCorrespondence[email protected]

Qin-Shi ZhaoState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming650204, ChinaCorrespondence[email protected]

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Abstract

Three new monoterpenoid indole alkaloids, 19-hydroxyl-10-methoxy-19, 20-dihydrovinorine (1), 19-O-acetyl-10-methoxy-19, 20-dihydrovinorine (2), and 19, 21α-dihydroxyl-10-methoxy-19, 20-dihydrovinorine (3), along with five known analogues (4–8), were isolated from the whole plants of Vinca major. The new structures were elucidated by extensive NMR and MS analysis and comparison with known compounds. In addition, compounds 1–3 were evaluated for their cytotoxicities against five human cancer cell lines.

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Three new monoterpenoid indole alkaloids from Vinca major

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Three new monoterpenoid indole alkaloids from Vinca major

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