Alkaloids with antioxidant activities from Aconitum handelianum

Abstract

A new C₂₀-diterpenoid alkaloid handelidine (1) and twenty-seven known alkaloids (2–28) were isolated from the roots of Aconitum handelianum. Their structures were established on the basis of extensive spectroscopic analyses. The study indicated that denudatine-type C₂₀-diterpenoid alkaloids with vicinal-triol system and benzyltetrahydroisoquinoline alkaloids exhibited significant antioxidant activities measured by three antioxidant test systems. The aconitine-type C₁₉-diterpenoid alkaloids could serve as potential secondary antioxidants for their strong binding effects to metal ions.

Keywords:

• Aconitum handelianum
• Ranunculaceae
• diterpenoid alkaloid
• handelidine
• antioxidant

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

This project was financially supported by grants from the National Natural Science Foundation of China (No. 81460648), the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT13095) and from the Postgraduate Foundation of Yunnan University (No. YNUY201415).

Additional information

Funding

This project was financially supported by grants from the National Natural Science Foundation of China [grant number 81460648]; the Program for Changjiang Scholars and Innovative Research Team in University [grant number IRT13095]; from the Postgraduate Foundation of Yunnan University [grant number YNUY201415].