Quinones and coumarins from Ajania salicifolia and their radical scavenging and cytotoxic activity

Abstract

1,4-Naphthoquinone (1) and a new coumarin (3) were isolated from Ajania salicifolia, together with two known compounds (2, 4). The structures and stereochemistry of new compounds were elucidated using spectroscopic methods. Two compounds exhibited potent ABTS cation radical scavenging activities with IC₅₀ values ranging 7.97–8.44 μM. Two quinones (1, 2) exhibited moderate cytotoxic activity against the human cancer cell lines (Hela, HepG2, and K562) with IC₅₀ values of 11.24–35.15 μM in vitro. This is the first report of naphthoquinone in the genus Ajania.

Keywords:

• Ajania salicifolia
• Asteraceae
• quinones
• coumarins
• radical scavenging capacity
• cytotoxicities

Disclosure statement

No potential conflict of interest was reported by the authors.