Three new aaptamine derivatives from the South China Sea sponge Aaptos aaptos

Jian-Hong GanKey Laboratory for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai200127, China;College of Food Science and Technology, Shanghai Ocean University, Shanghai201306, China

Wen-Zhen HuCollege of Food Science and Technology, Shanghai Ocean University, Shanghai201306, China

Hao-Bing YuKey Laboratory for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai200127, China;Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai200433, China

Fan YangKey Laboratory for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai200127, China

Meng-Xue CaoKey Laboratory for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai200127, China

Hua-Jin ShiCollege of Food Science and Technology, Shanghai Ocean University, Shanghai201306, China

Yong-Feng KangCollege of Food Science and Technology, Shanghai Ocean University, Shanghai201306, ChinaCorrespondence[email protected]

Bing-Nan HanKey Laboratory for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai200127, ChinaCorrespondence[email protected]

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Abstract

Three new aaptamine derivatives (1–3), together with six known related compounds (4–9), have been isolated from the South China Sea sponge Aaptos aaptos. The structures of all compounds were unambiguously elucidated on the basis of spectroscopic analyses. Compounds 1, 4, 5, 7, and 9 showed cytotoxic activities against HeLa, K562, MCF-7, and U937 cell lines with IC₅₀ values in the range of 0.90–12.32 μM.

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Three new aaptamine derivatives from the South China Sea sponge Aaptos aaptos

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Three new aaptamine derivatives from the South China Sea sponge Aaptos aaptos

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