Sesquiterpenoids and further diterpenoids from the rare Chloranthaceae plant Chloranthus sessilifolius

Abstract

Two new dimeric lindenane-type sesquiterpenoids (1 and 2, named chlorasessilifols A and B, resp.), one new ent-podocarpane-type C₁₇ norditerpenoid (3), and one new ent-torarane-type diterpenoid (4), along with seven known terpenoids, were isolated from the whole plant of Chloranthus sessilifolius. The new structures were established by means of spectroscopic methods and/or observed cotton effects in the circular dichroism spectra. Among the isolates, 3α,7β-dihydroxy-ent-abieta-8,11,13-triene (11) exhibited significant anti-neuroinflammatory activity by inhibiting the nitric oxide production in lipopolysaccharide-stimulated murine BV-2 microglial cells, with an IC₅₀ value of 4.3 μM.

Keywords:

• Chloranthus sessilifolius
• Chloranthaceae
• sesquiterpenoids
• diterpenoids
• anti-neuroinflammation

Acknowledgments

The authors thank Prof. Bao-Kang Huang (Department of Pharmacognosy, Second Military Medical University of China) for the identification of the plant material.

Disclosure statement

No potential conflict of interest was reported by the authors.