Synthesis and antitumor activity evaluation of lamiridosin A derivatives

Abstract

A series of lamiridosin A derivatives were synthesized through simple procedures. Their antitumor activities were evaluated against EC9706, MGC803, and B16 cell lines in vitro. Several compounds showed potent antitumor activity, especially compound 10, with IC₅₀ value of 2.36 μmol/L against MGC803 cell lines, is more potent than marketed positive drug 5-fluorouridine (5-FU).

Keywords:

• Lamiridosin A
• iridoids
• ether derivatives
• triazole
• antitumor