Cytisine-type alkaloids and flavonoids from the rhizomes of Sophora tonkinensis

Abstract

A new cytisine-type alkaloid, (−)-N-hexanoylcytisine (1), and a new isoflavan, (3S, 4R)-4-hydroxy-7,4′-dimethoxyisoflavan 3′-O-β-d-glucopyranoside (2), along with 10 known compounds, were isolated from the rhizomes of Sophora tonkinensis. Their structures were determined by spectroscopic methods, chemical evidence, and ECD data analysis. All of the isolates were evaluated for their cytotoxic activities against four human tumor cell lines.

Keywords:

• Leguminosae
• Sophora tonkinensis
• cytisine-type alkaloid
• isoflavan
• cytotoxic activity

Disclosure statement

No potential conflict of interest was reported by the authors.