An unusual sesquiterpene coumarin from the seeds of Ferula sinkiangensis

Abstract

A sesquiterpene coumarin, sinkiangenorin E, consisting of a novel bicyclo[4.3.1]decane-type sesquiterpene system, was isolated from the seeds of Ferula sinkiangensis. The structure of sinkiangenorin E including the relative stereochemistry and the absolute configuration was elucidated on the basis of spectroscopic data. The new compound showed cytotoxic activity against AGS cells (IC₅₀, 12.7 μM) and inhibiting effect against influenza A H₁N₁ (IC₅₀, 4.0 μM), which provided important clues for the study on the bioactivities of this type of sesquiterpene coumarins.

Keywords:

• Apiaceous
• Ferula sinkiangensis
• sesquiterpene coumarin
• cytotoxic activity
• antiviral activity