Diarylpentanol constituents from the aerial part of Stelleropsis tianschanica

Lei-Ling ShiKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Beijing100193, China;Department of Natural Medicinal Chemistry, Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi830002, China

Guo-Xu MaKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Beijing100193, China;Department of Natural Medicinal Chemistry, Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi830002, China

Hua-Chun GaoSchool of Pharmaceutical Sciences, Xiamen University, Xiamen361102, China

Quan-Cheng ChenSchool of Pharmaceutical Sciences, Xiamen University, Xiamen361102, China

Jun-Shan YangKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Beijing100193, China

Xiao-Guang JiaDepartment of Natural Medicinal Chemistry, Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi830002, ChinaCorrespondence[email protected]

Jing ZhangCollege of Chinese Medicinal Material, Jilin Agricultural University, Changchun130118, ChinaCorrespondence[email protected]

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Abstract

Five diarylpentanol derivatives including two new compounds stellerasme A (1), stellerasme B (2) were isolated from the aerial parts of Stelleropsis tianschanica. Their structures were elucidated by various spectroscopic techniques (UV, IR, MS, CD, 1D and 2D NMR). All compounds were evaluated for their cytotoxicity activity against HeLa and KB cell lines, and compound 1 showed selective activities against HeLa cell line with an IC₅₀ value of 7.4 μM.

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Diarylpentanol constituents from the aerial part of Stelleropsis tianschanica

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