Total synthesis of xiamenmycin C and all of its stereoisomers: stereochemical revision

Yang-Yang YaoState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Science & Pecking Union Medical College, Beijing 100050, China

Xiao-Yu LiuState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Science & Pecking Union Medical College, Beijing 100050, China

Xiao-Yu LiState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Science & Pecking Union Medical College, Beijing 100050, China

Hong-Guang YangState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Science & Pecking Union Medical College, Beijing 100050, China

Li LiState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Science & Pecking Union Medical College, Beijing 100050, China

Xiao-Zhen JiaoState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Science & Pecking Union Medical College, Beijing 100050, ChinaCorrespondence[email protected]

Ping XieState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Science & Pecking Union Medical College, Beijing 100050, ChinaCorrespondence[email protected]

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Abstract

Xiamenmycin C, a potent anti-fibrotic natural product, and all of its stereoisomers have been synthesized and their structures were fully characterized. Based on this study, the originally proposed structure of xiamenmycin C has been accordingly revised to be 2R,3S.

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Total synthesis of xiamenmycin C and all of its stereoisomers: stereochemical revision

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Total synthesis of xiamenmycin C and all of its stereoisomers: stereochemical revision

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