Chemical study of the fungus Psilocybe merdaria

Abstract

Chemical investigation on the cultures of the fungus Psilocybe merdaria resulted in the first isolation of 10 compounds including two new ones 11,14-dihydroxylneoechinulin E (1) and (S)-4-(4-methylpent-3-en-1-yl)-butyrolactone (2). Their structures were elucidated from the analysis of 1D and 2D NMR and MS data. Among them, compound 7 showed inhibitory activity against AChE with 20% percentage at a concentration of 50 μg/ml.

Keywords:

• Psilocybe
• Psilocybe merdaria
• indole alkaloids
• AChE inhibitory activity

Acknowledgments

The authors are grateful to the members of the analytical group of Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences for the spectral measurements.