Two new phenolic acids from the fruits of Forsythia suspense

Xin-Jia YanCollege of Pharmacy, Harbin University of Commerce, Harbin150076, China;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang110016, ChinaCorrespondence[email protected]

Jing WenCollege of Pharmacy, Harbin University of Commerce, Harbin150076, China;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang110016, China

Zheng XiangCollege of Pharmacy, Harbin University of Commerce, Harbin150076, China

Dong CaiKey Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang110016, China

Chong-Ning LvSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang110016, China

Ying ZhaoCollege of Pharmacy, Harbin University of Commerce, Harbin150076, China

Zhong-Yuan QuCollege of Pharmacy, Harbin University of Commerce, Harbin150076, China

Yu-Jia LiuCollege of Pharmacy, Harbin University of Commerce, Harbin150076, China

Jia-Lin QuSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang110016, China

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Abstract

Two new phenolic acids forsythiayanoside C (1) and forsythiayanoside D (2), were isolated from the fruits of Forsythia suspense (Thunb.) Vahl. Their structures were elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses, HRESIMS and CD spectrometry. The cytotoxic and antioxidant activities testing showed that compound 2 exhibited free radical scavenging activity.

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Acknowledgments

Authors thank Mrs. Ying Peng, Mrs. Wen Li and Mr. Yi Sha of Shenyang Pharmaceutical University for their support in recording of HRESIMS and NMR spectra.

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Two new phenolic acids from the fruits of Forsythia suspense

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Two new phenolic acids from the fruits of Forsythia suspense

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