New macrocyclic lactones with acaricidal and nematocidal activities from a genetically engineered strain Streptomyces bingchenggensis BCJ60

Jian-Song LiLife Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin150030, China

Hui ZhangDepartment of New Drug Screening, Zhejiang Hisun Pharmaceutical Co., Ltd, Taizhou318000, China

Shao-Yong ZhangProvincial Joint Engineering Laboratory of Biopesticide Preparation, School of Forestry & Biotechnology, Zhejiang Agricultural and Forestry University, Lin’An311300, China

Hai-Yan wangLife Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin150030, China

Ji ZhangLife Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin150030, China

An-Liang ChenProvincial Joint Engineering Laboratory of Biopesticide Preparation, School of Forestry & Biotechnology, Zhejiang Agricultural and Forestry University, Lin’An311300, China

Ji-Dong WangProvincial Joint Engineering Laboratory of Biopesticide Preparation, School of Forestry & Biotechnology, Zhejiang Agricultural and Forestry University, Lin’An311300, China;Department of New Drug Screening, Zhejiang Hisun Pharmaceutical Co., Ltd, Taizhou318000, ChinaCorrespondence[email protected]

Wen-Sheng XiangLife Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin150030, ChinaCorrespondence[email protected]

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Abstract

Two new macrocyclic lactones, 4,25-diethyl-4,25-demethyl-milbemycin β₃ (1) and 27-formaldehyde-milbemycin β₁₄ (2), were isolated from a genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as ESI-MS and comparison with data from the literature. The acaricidal and nematocidal capacities of compounds 1 and 2 were evaluated against Tetranychus cinnabarinus and Bursaphelenchus xylophilus, respectively. The results showed that the two new macrocyclic lactones 1 and 2 possessed potent acaricidal and nematocidal activities.

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New macrocyclic lactones with acaricidal and nematocidal activities from a genetically engineered strain Streptomyces bingchenggensis BCJ60

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New macrocyclic lactones with acaricidal and nematocidal activities from a genetically engineered strain Streptomyces bingchenggensis BCJ60

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