A novel 3,4-dihydronaphthalen-1(2H)-one with spiro-butyrolactone and a new isocoumarin isolated from the endophytic fungus Phoma sp. YN02-P-3

Xia-Nan SangKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China

Shao-Fei ChenKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China

Xiao AnKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China

Gang ChenKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China

Hai-Feng WangKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, ChinaCorrespondence[email protected]

Yue-Hu PeiKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, ChinaCorrespondence[email protected]

Abstract

A novel 3,4-dihydronaphthalen-1(2H)-one with spiro-butyrolactone phomol (1) and a new isocoumarin phomasatin (2), together with two known compounds (3–4) were isolated from the solid culture of the endophytic fungus Phoma sp. YN02-P-3. Their structures including the absolute configurations were characterized on the basis of extensive 1D, 2D NMR (HSQC, HMBC, NOESY), MS, and CD spectral data. Compound 1 showed selective cytotoxic activity against HL-60 cell line with the IC₅₀ value of 29.05 μM.

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A novel 3,4-dihydronaphthalen-1(2H)-one with spiro-butyrolactone and a new isocoumarin isolated from the endophytic fungus Phoma sp. YN02-P-3

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A novel 3,4-dihydronaphthalen-1(2H)-one with spiro-butyrolactone and a new isocoumarin isolated from the endophytic fungus Phoma sp. YN02-P-3

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