Abstract
During the process of icogenin analog research, we obtained two cytotoxic steroids: compound 4 and compound 6 casually. Their in vitro antitumor activities were tested by the standard MTT assay. The results disclosed that compound 4 (IC50 = 3.65–6.90 μM) showed potential antitumor activities against HELA, KB cell lines and compound 6 (IC50 = 2.40–9.05 μM) showed potential antitumor activities against HELA, BGC-823, KB, A549, HCT-8 cell lines.
Acknowledgment
Financial support of this research by National Program of New Drug Innovation and Production (2009ZX09301- 003-9-1) is gratefully acknowledged by authors.