Two new C-glucosyl flavonoids from Ziziphus jujube and their anti-inflammatory activity

Abstract

Two new C-glucosyl flavonoids 6′′-O-feruloylspinosin and 6′′-O-feruloyl-6′′′-p-hydroxybenzoylspinosin, together with five known compounds, were isolated from the seeds of Ziziphus jujube (Rhamnaceae family). Their structures were elucidated on the basis of chemical and spectroscopic evidences. Compounds 1–7 showed moderate inhibitory effects against COX-1 and COX-2 enzymes.

Keywords:

• Rhamnaceae
• Ziziphus jujube
• C-glucosyl flavonoids
• COX inhibiting activity