235
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

Synthesis and anti-inflammatory evaluation of novel paclitaxel analogs

, , &
Pages 803-822 | Received 10 Mar 2016, Accepted 12 Sep 2016, Published online: 18 Oct 2016
 

Abstract

A series of paclitaxel analogs modified at C-3′-N and C-7 positions were synthesized from baccatin III and their structures were confirmed by 1H-NMR, 13C-NMR, HR-MS. Compound 7e exhibited potent ability to decrease TNFα (tumor necrosis factor α) in the LPS-activated RAW264.7 murine macrophage-like cell line. The preliminary data indicated that the anti-inflammatory effects may be related to MD-2 and Toll-like receptor 4 (TLR4), rather than Toll-like receptor 2 (TLR2).

Acknowledgments

The authors are grateful to Prof. Lei Li and Yan Tan, Research Institute of Surgery, Third Military Medical University, for their help in the activity assay. We also thank Dr H. Deng, The Instrumental Analysis & Research Center of Shanghai University, for structural analysis.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.